- Description
- Deciphers the heterogeneity and diversity of profiles of functional signals (e.g., chromatin mark ChIP-seq signal) centered at a collection of sites (e.g., TSSs or TF binding sites) in a genome. Rather than averaging the profiles over all the anchor sites (traditional aggregation plots), CAGT accounts for the inherent heterogeneity in signal magnitude, shape and implicit strand orientation of chromatin marks. CAGT partitions the set of anchor sites into compact clusters such that each cluster represents anchor points that show similar patterns of the functional signal profiles with different clusters having distinct patterns. The different groups of patterns are often enriched for distinct biological functions (PMID: 22955985).
- Software type
- genome segmentation
- Used for
- integrative analysis