ENCODE: Encyclopedia of DNA Elements



The ENCODE (Encyclopedia of DNA Elements) Consortium is an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI). The goal of ENCODE is to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.

Image credits: Darryl Leja (NHGRI), Ian Dunham (EBI), Michael Pazin (NHGRI)





To find and download ENCODE Consortium data:

ENCODE investigators employ a variety of assays and methods to identify functional elements. The discovery and annotation of gene elements is accomplished primarily by sequencing a diverse range of RNA sources, comparative genomics, integrative bioinformatic methods, and human curation. Regulatory elements are typically investigated through DNA hypersensitivity assays, assays of DNA methylation, and immunoprecipitation (IP) of proteins that interact with DNA and RNA, i.e., modified histones, transcription factors, chromatin regulators, and RNA-binding proteins, followed by sequencing.

All ENCODE data is freely available for download and analysis. Please refer to the ENCODE Data Release Policy


Registration now open: ENCODE User's Meeting will be held at at the Bolger Center in Potomoc, MD from June 29 - July 1, 2015 [read more]

December 17, 2014: Data release: 114 human and 98 mouse datasets. [read more]

December 8, 2014: Data release: 10 human, 25 mouse, and 108 fly datasets. [read more]

December 1, 2014: Recent publications by the ENCODE Consortium and community publications using ENCODE data have been added to the publications page [read more]

November 20, 2014: Data release: 88 human and 11 mouse datasets. [read more]

November 19, 2014: Mouse ENCODE Consortium papers published [read more]

November 19, 2014: Create custom track hubs from a search result [read more]

See news archive for additional news and updates.