ENCODE: Encyclopedia of DNA Elements



The ENCODE (Encyclopedia of DNA Elements) Consortium is an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI). The goal of ENCODE is to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.

Image credits: Darryl Leja (NHGRI), Ian Dunham (EBI), Michael Pazin (NHGRI)




Quick Start

To find and download ENCODE Consortium data:

Additional help using the ENCODE Portal:

ENCODE investigators employ a variety of assays and methods to identify functional elements. The discovery and annotation of gene elements is accomplished primarily by sequencing a diverse range of RNA sources, comparative genomics, integrative bioinformatic methods, and human curation. Regulatory elements are typically investigated through DNA hypersensitivity assays, assays of DNA methylation, and immunoprecipitation (IP) of proteins that interact with DNA and RNA, i.e., modified histones, transcription factors, chromatin regulators, and RNA-binding proteins, followed by sequencing.

All ENCODE data is freely available for download and analysis. Please refer to the ENCODE Data Release Policy


Oct 6, 2015We are pleased to announce that the metadata from 3127 Roadmap experiments have been released on the ENCODE Portal

Aug 31, 2015: The presentation video and tutorials from the ENCODE 2015: Research Applications and Users Meeting have been posted for public use.

June 29 to July 1, 2015: The ENCODE 2015: Research Applications and Users Meeting was held at at the Bolger Center in Potomoc, MD

June 23, 2015: Data release: 3 human and 91 mouse datasets. [read more]

May 28, 2015: Changelog released for metadata schema updates. [read more]

May 18, 2015: Data release: 12 human datasets. [read more]

May 13, 2015: 519 publications that use ENCODE data, published by authors not funded by ENCODE, added to the ENCODE Portal [read more]

April 13, 2015: Data release: 28 human datasets. [read more]

March 31, 2015: Data release: 4 human datasets. [read more]

March 11, 2015: Experiment pages have been updated to show a graphical display of the pipeline used to generate the processed files associated with that experiment. [read more]

See our news archive for additional news and updates.