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  • MPRA in K562
    Homo sapiens K562, 24 hours post-nucleic acid delivery time genetically modified (episome) using transient transfection
    Lab: Ryan Tewhey, JAX
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR341GVP
    released
  • MPRA in K562
    Homo sapiens K562, 24 hours post-nucleic acid delivery time genetically modified (episome) using transient transfection
    Lab: Ryan Tewhey, JAX
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR909JVP
    released
  • MPRA in K562
    Homo sapiens K562, 24 hours post-nucleic acid delivery time genetically modified (episome) using transient transfection
    Lab: Ryan Tewhey, JAX
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR820RPI
    released
  • MPRA in K562
    Elements cloned into the lentiMPRA vector upstream of a minimal promoter, with barcode located in the 5' UTR of the reporter. Elements test potential HepG2, K562, and WTC11 enhancers and promoters of all protein-coding genes.
    Lab: Nadav Ahituv, UCSF
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR203UFY
    released
  • STARR-seq in K562
    Homo sapiens K562 genetically modified (episome) using transient transfection
    Lab: Tim Reddy, Duke
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR926NDZ
    released
  • perturbation followed by snATAC-seq in K562
    K562 cell line genetically modified (insertion) using transduction, genetically modified (CRISPRi) using CRISPR
    Assays: perturbation followed by snATAC-seq
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Series
    ENCSR513XAG
    released
  • CRISPR cutting screen of GATA1 locus in K562
    Homo sapiens K562 genetically modified (insertion) using transduction (low MOI), using CRISPR cutting (sgRNA) for GATA1 locus
    Assays: CRISPR screen
    Lab: Yin Shen, UCSF
    Project: ENCODE
    Loci: GATA1
    Tiling modality: peak tiling
    Series
    ENCSR825HCS
    released
  • MPRA of PKLR locus in K562
    Elements cloned into the pGL4.11 vector upstream of the reporter, with barcode located in the 3' UTR of the reporter. Elementas are generated by error-prone PCR of the PKLR promoter.
    Loci: PKLR
    Lab: Nadav Ahituv, UCSF
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR987WTK
    released
  • MPRA of PKLR locus in K562
    Elements cloned into the pGL4.11 vector upstream of the reporter, with barcode located in the 3' UTR of the reporter. Elementas are generated by error-prone PCR of the PKLR promoter.
    Loci: PKLR
    Lab: Nadav Ahituv, UCSF
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR845WND
    released
  • CRISPRi proliferation screen of multiple loci in K562
    Homo sapiens K562 genetically modified (insertion) using transduction, using CRISPRi (pgRNA) for multiple loci
    Assays: proliferation CRISPR screen
    Lab: Bing Ren, UCSD
    Project: ENCODE
    Loci: MYC, MYB
    Tiling modality: full tiling
    Series
    ENCSR411TAL
    released
  • MPRA in K562
    Homo sapiens K562, 24 hours post-nucleic acid delivery time genetically modified (episome) using transient transfection
    Elements selection method: sequence variants
    Lab: Ryan Tewhey, JAX
    Project: ENCODE
    Functional Characterization Experiment
    ENCSR971PLA
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series of CRISPRi (dCas9-KRAB) growth screen targeting putative essential DHSs in K562 .(validation screen in K562).
    Assays: proliferation CRISPR screen
    Lab: Tim Reddy, Duke
    Project: ENCODE
    Tiling modality: sparse peak
    Series
    ENCSR274OEB
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series of CRISPRi (dCas9-KRAB) growth screen targeting all previously identified open chromatin regions (DHSs) in K562. (Discovery screen).
    Assays: proliferation CRISPR screen
    Lab: Tim Reddy, Duke
    Project: ENCODE
    Tiling modality: peak tiling
    Series
    ENCSR690DTG
    released
  • CRISPRi Flow-FISH screen in K562 with HCR-FlowFISH readout of HBS1L
    Functional characterization series for the gene target HBS1L.
    Assays: Flow-FISH CRISPR screen
    Lab: Pardis Sabeti, Broad
    Project: ENCODE
    Tiling modality: full tiling
    Series
    ENCSR759RSA
    released
  • CRISPRi Flow-FISH screen in K562 with HCR-FlowFISH readout of MYB
    Functional characterization series for the gene target MYB.
    Assays: Flow-FISH CRISPR screen
    Lab: Pardis Sabeti, Broad
    Project: ENCODE
    Tiling modality: full tiling
    Series
    ENCSR408VHJ
    released
  • CRISPRi Flow-FISH screen in K562 with HCR-FlowFISH readout of HBE1
    Functional characterization series for the gene target HBE1.
    Assays: Flow-FISH CRISPR screen
    Lab: Pardis Sabeti, Broad
    Project: ENCODE
    Tiling modality: full tiling
    Series
    ENCSR564EPW
    released
  • CRISPRi Flow-FISH screen in K562 with HCR-FlowFISH readout of HBG2
    Functional characterization series for the gene target HBG2.
    Assays: Flow-FISH CRISPR screen
    Lab: Pardis Sabeti, Broad
    Project: ENCODE
    Tiling modality: full tiling
    Series
    ENCSR459QNY
    released
  • CRISPRi Flow-FISH screen in K562 with HCR-FlowFISH readout of HBG1
    Functional characterization series for the gene target HBG1.
    Assays: Flow-FISH CRISPR screen
    Lab: Pardis Sabeti, Broad
    Project: ENCODE
    Tiling modality: full tiling
    Series
    ENCSR449NJV
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series for CRISPRi/dCas9-RYBP sparse-tiling proliferation screens at ~7500 cCREs around ~450 essential genes in K562
    Assays: proliferation CRISPR screen
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Elements selection method: DNase hypersensitive sites
    Tiling modality: sparse peak
    Series
    ENCSR369UFO
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series for CRISPRi/dCas9-KRAB-WSR7EEE sparse-tiling proliferation screens at ~7500 cCREs around ~450 essential genes in K562
    Assays: proliferation CRISPR screen
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Elements selection method: DNase hypersensitive sites
    Tiling modality: sparse peak
    Series
    ENCSR386FFV
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series for CRISPRi/dCas9-KRAB-MGA1-MGA2 sparse-tiling proliferation screens at ~7500 cCREs around ~450 essential genes in K562
    Assays: proliferation CRISPR screen
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Elements selection method: DNase hypersensitive sites
    Tiling modality: sparse peak
    Series
    ENCSR427OCU
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series for dCas9-ZNF705-KRAB/CRISPRi tiling proliferation screens at a subset of cCREs around essential genes
    Assays: proliferation CRISPR screen
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Elements selection method: DNase hypersensitive sites
    Tiling modality: peak tiling
    Series
    ENCSR372CKT
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series for dCas9-RYBP/CRISPRi tiling proliferation screens at a subset of cCREs around essential genes
    Assays: proliferation CRISPR screen
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Elements selection method: DNase hypersensitive sites
    Tiling modality: peak tiling
    Series
    ENCSR381RDB
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series for dCas9-KRAB-WSR7EEE/CRISPRi tiling proliferation screens at a subset of cCREs around essential genes
    Assays: proliferation CRISPR screen
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Elements selection method: DNase hypersensitive sites
    Tiling modality: peak tiling
    Series
    ENCSR295VER
    released
  • CRISPRi proliferation screen in K562
    Functional characterization series for dCas9-KRAB/CRISPRi tiling proliferation screens at a subset of cCREs around essential genes
    Assays: proliferation CRISPR screen
    Lab: Will Greenleaf, Stanford
    Project: ENCODE
    Elements selection method: DNase hypersensitive sites
    Tiling modality: peak tiling
    Series
    ENCSR446RYW
    released