Characterization and Radiosensitivity at High or Low Dose Rate of Four Cell Lines derived from Human Thyroid Tumors
International Journal of Radiation Oncology Biol. Phys.. 1997;37(1):163-169.
- Abstract
- Purpose: This study attempted to establish cell lines derived from human differentiated thyroid tumors, and to characterize and evaluate the radiation dose-rate effect. Methods and l+Sateriais: Two cell lines (Kl and K2) were derived from papilhq carcinomas, one (K7) from a follicular less-dtfferentlated carcinoma and one (A14) radiition were established by the in vitro colony meth Gy/h) or low dose rate (0.6 Gy/h) by a “Co source. T and multltarget model of radiation action. Results: Doubling times were around 24 h. All cell lines were positive for httracelhdar adenosine monophosphate (CAMP) response to thyrotropm (TSH) was fortheceIllhmsdori~from the follbmlar adenoma and follicular carchmma. The two cell lines derived from -Were tumorigenic after ino&ation into nude mice. (SF2) was not signigcantly different for the thr 0.42. For the adenoma cell line A14, we found parameter. After low-dose-rate irradiation, only one cell line (K2) showed a signiiant low-dose-rate sparhtg with a dose reduction factor of 1.35. Conclusion: The major result of our study is the weak effect of the dose rate on the survival of thyroid cell lines.
- References